Jhdma2a Gene Hope Sparks For Curing Infertility

 Jhdma2a Gene Hope Sparks For Curing Infertility

 A recent discovery that plays a key role in the formation of sperm could shed light on the issue of male infertility. A deficiency in the Jhdma2a gene, according to scientists at the Howard Hughes Medical Institute, may be the cause of some cases of infertility in men.

Mice lacking the Jhdma2a gene were infertile and produced only a small number of defective sperm, according to the Howard Hughes research. One of the UK's leading male fertility doctors had great expectations that the discovery might provide insight into why some men are unable to father children. Many of the factors that contribute to male "infertility" are yet unknown.

Some men are unable to father a child for a variety of reasons, including abnormally shaped sperm or a low sperm count. Many studies are looking into genetic abnormalities as a possible cause of various diseases. The Jhdma2a gene, according to Howard Hughes' team of experts, is essential for "spermiogenesis," which permits the DNA needed to produce an embryo to be compacted into a tight ball inside the sperm's head so that it may burst through the egg's outer membrane. Spermiogenesis is the ultimate step of sperm maturation, when the cell develops its pseudopod, gains the capacity to crawl, and is ready to fertilize an oocyte.

They tested on mice and bred these animals without the Jhdma2a gene to see if the Jhdma2a gene could alter sperm production. These mice were discovered to have abnormally small testes, a low number of sperm production, and were unable to reproduce. Not only do these mice have very small testes, but the sperm they generate have irregularly shaped heads and tails that are immovable, according to the researchers. When the sperm were dyed and studied under a microscope, it was discovered that the DNA was not packaged correctly in the sperm head.

 Jhdma2a Gene Hope Sparks For Curing Infertility

According to Dr. Yi Zhang, project leader of the Howard Hughes team, “defects in this gene could explain the cause of some cases of male infertility.” “Because this gene has such a narrow effect on the formation of functioning sperm, it has a lot of potential as a target for future infertility treatments that won't disturb other body functions,” he added.

Although the Jhdma2a gene's importance has been demonstrated in mice, there is no guarantee that it will have the same effect in people. The team's next significant step is to focus on infertile men's DNA to discover if it's absent in any of them.

The genes that governed sperm production were poorly understood, according to Dr. Allan Pacey, a senior lecturer in Andrology at the University of Sheffield and Secretary of the British Fertility Society. “The packaging of sperm DNA into the sperm head is highly distinctive, and we know very little about it. This discovery should be translated into human males to investigate if it can explain why some men simply don't generate healthy sperm and are so infertile,” he said.